Hypersonic aircraft is a major direction of the world aerospace development in 21st century,which will bring significant changes to the world military,and form the new focus of air and space confrontation.Under this background,the infrared (IR) imaging guidance technology which is combined by optical,machine,and electricity,can provide a powerful means to improve the attack accuracy of various hypersonic weapons.However,the IR imaging of hypersonic seeker in dense atmosphere is faced with serious aero-optical effect,which seriously restricts the application of infrared imaging in hypersonic seeker.The application prospect of infrared imaging in precision strike of hypersonic weapon was analyzed.The major technical difficulties in the development process of this technology were discussed.Last but not least,some solutions and ideas were put forward.